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Reply to: Binding site for MDL-801 on SIRT6

The Original Article was published on 01 March 2021

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Fig. 1: MDL-801 at the SIRT6 site.

Data availability

The crystal structures of apo SIRT6 and SIRT6 in complex with MDL-801 have been deposited in the PDB under accession codes 7CL0 and 7CL1, respectively.


  1. 1.

    You, W. & Steegborn, C. Binding site for MDL-801 on SIRT6. Nat. Chem. Biol. (2021).

  2. 2.

    Huang, Z. et al. Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol. 14, 1118–1126 (2018).

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    Jiang, H. et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110–113 (2013).

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Author information




Z.H., J.S. and K.S. performed the biological experiments and the crystallography. K.S. solved the crystal structures and analyzed the data. J. Zhang, S.L. and H.S. discussed the manuscript, J. Zhang and S.L. wrote the manuscript and J. Zhao, W.D., Y.C., L.Z., C.W., X.Y., B.H., J.M., H.H., M.T., J.X., Q.Z., J. Zhong, X.S., Z.M., H.L., M.X., Y.E.C., H.J., Y.X. and G.C. are the authors of our previous paper2.

Corresponding author

Correspondence to Jian Zhang.

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Competing interests

The group of J. Zhang has a collaboration with Shanghai Ailewei on SIRT6.

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Huang, Z., Zhao, J., Deng, W. et al. Reply to: Binding site for MDL-801 on SIRT6. Nat Chem Biol (2021).

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