Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell death

STACKing the odds for discoveries

Nature Chemical Biology volume 17, pages 627–628 (2021)Cite this article

Subjects

Characterization of cell death kinetics identifies new on- and off-target small-molecule modulators of ferroptosis and reveals a role of amino acid metabolism in regulating ferroptosis sensitivity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: STACK reveals on- and off-target modulators of ferroptosis.

References

  1. Galluzzi, L. et al. Cell Death Differ. 25, 486–541 (2018).

    Article  Google Scholar 

  2. Conlon, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00751-4 (2021).

  3. Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    Article  CAS  Google Scholar 

  4. Soula, M. et al. Nat. Chem. Biol. 16, 1351–1360 (2020).

    Article  CAS  Google Scholar 

  5. Zhang, Y. et al. Cell Chem. Biol. 26, 623–633.e9 (2019).

    Article  CAS  Google Scholar 

  6. Ubellacker, J. M. et al. Nature 585, 113–118 (2020).

    Article  CAS  Google Scholar 

  7. Viswanathan, V. S. et al. Nature 547, 453–457 (2017).

    Article  CAS  Google Scholar 

  8. Fallahi-Sichani, M., Honarnejad, S., Heiser, L. M., Gray, J. W. & Sorger, P. K. Nat. Chem. Biol. 9, 708–714 (2013).

    Article  CAS  Google Scholar 

  9. Forcina, G. C., Conlon, M., Wells, A., Cao, J. Y. & Dixon, S. J. Cell Syst. 4, 600–610.e6 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA

    Mariluz Soula & Kıvanç Birsoy

Authors
  1. Mariluz Soula
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kıvanç Birsoy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kıvanç Birsoy.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Soula, M., Birsoy, K. STACKing the odds for discoveries. Nat Chem Biol 17, 627–628 (2021). https://doi.org/10.1038/s41589-021-00743-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-021-00743-4

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing