Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mabbitt, P. D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0598-6 (2020)
Buetow, L. & Huang, D. T. Nat. Rev. Mol. Cell Biol. 17, 626–642 (2016).
Lorenz, S. Biol. Chem. 399, 127–145 (2018).
Dove, K. K. & Klevit, R. E. J. Mol. Biol. 429, 3363–3375 (2017).
Walden, H. & Rittinger, K. Nat. Struct. Mol. Biol. 25, 440–445 (2018).
Pao, K. C. et al. Nat. Chem. Biol. 12, 324–331 (2016).
Pao, K. C. et al. Nature 556, 381–385 (2018).
Ahel, J. et al. eLife 9, e56185 (2020).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Lorenz, S., Rittinger, K. Advanced rules of relays. Nat Chem Biol 16, 1158–1159 (2020). https://doi.org/10.1038/s41589-020-0632-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-020-0632-8