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Advanced rules of relays

Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.

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Fig. 1: Schematic of ubiquitin ligase (E3) mechanisms, featuring the interactions of the catalytic region of the respective E3 with a ubiquitin (Ub)-loaded E2.


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Correspondence to Sonja Lorenz or Katrin Rittinger.

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The authors declare no competing interests.

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Lorenz, S., Rittinger, K. Advanced rules of relays. Nat Chem Biol 16, 1158–1159 (2020).

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