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Living cells as test tubes

Thermodynamic principles are used to map the phase behavior of a tunable protein-binding system under crowded cellular conditions. This study marks a substantial step forward in relating molecular interactions to material properties and cellular processes involving protein self-assembly.

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Fig. 1: Studying self-assembly of well-defined protein binding systems using a unified toolset.


  1. Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. 18, 285–298 (2017).

    Article  CAS  Google Scholar 

  2. Brangwynne, C. P., Tompa, P. & Pappu, R. V. Nat. Phys. 11, 899 (2015).

    Article  CAS  Google Scholar 

  3. Murthy, A. C. et al. Nat. Struct. Mol. Biol. 26, 637–648 (2019).

    Article  CAS  Google Scholar 

  4. Vernon, R. M. et al. eLife 7, e31486 (2018).

    Article  Google Scholar 

  5. Heidenreich, M. et al. Nat. Chem. Biol. (2020).

    Article  PubMed  Google Scholar 

  6. Conicella, A. E. et al. Proc. Natl Acad. Sci. USA 117, 5883–5894 (2020).

    Article  CAS  Google Scholar 

  7. Schuster, B. S. et al. Proc. Natl Acad. Sci. USA 117, 11421–11431 (2020).

    Article  CAS  Google Scholar 

  8. Martin, E. W. et al. 367, 694–699 (2020).

  9. Falahati, H. & Wieschaus, E. Proc. Natl Acad. Sci. USA 114, 1335–1340 (2017).

    Article  CAS  Google Scholar 

  10. Tauber, D., Tauber, G. & Parker, R. Trends Biochem. Sci. (2020).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Jeetain Mittal.

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Mammen Regy, R., Mittal, J. Living cells as test tubes. Nat Chem Biol 16, 934–935 (2020).

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