GLYCOBIOLOGY

Targeted self-destruction

Altered glycosylation helps cancer cells evade immune destruction, and targeted remodeling of glycans in vivo offers the ability to reprogram immune responses. A stable chemical linkage between an antibody and neuraminidase enables the targeted destruction of self-associated sialic acids to enhance antitumor immunity.

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Fig. 1: Targeted in vivo desialylation of tumors.

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Correspondence to Matthew S. Macauley.

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Rodrigues, E., Macauley, M.S. Targeted self-destruction. Nat Chem Biol (2020). https://doi.org/10.1038/s41589-020-0612-z

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