Altered glycosylation helps cancer cells evade immune destruction, and targeted remodeling of glycans in vivo offers the ability to reprogram immune responses. A stable chemical linkage between an antibody and neuraminidase enables the targeted destruction of self-associated sialic acids to enhance antitumor immunity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Qin, S. et al. Mol. Cancer 18, 155 (2019).
Kalbasi, A. & Ribas, A. Nat. Rev. Immunol. 20, 25–39 (2020).
RodrÍguez, E., Schetters, S. T. T. & van Kooyk, Y. Nat. Rev. Immunol. 18, 204–211 (2018).
Duan, S. & Paulson, J. C. Annu. Rev. Immunol. 38, 365–395 (2020).
Läubli, H. & Varki, A. Cell. Mol. Life Sci. 77, 593–605 (2020).
Gray, M. A. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0622-x (2020).
Xiao, H., Woods, E. C., Vukojicic, P. & Bertozzi, C. R. Proc. Natl Acad. Sci. USA 113, 10304–10309 (2016).
Läubli, H. et al. Proc. Natl Acad. Sci. USA 111, 14211–14216 (2014).
Büll, C. et al. Cancer Res. 78, 3574–3588 (2018).
Cornelissen, L. A. M. et al. Int. J. Cancer 144, 2290–2302 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Rodrigues, E., Macauley, M.S. Targeted self-destruction. Nat Chem Biol 16, 1281–1283 (2020). https://doi.org/10.1038/s41589-020-0612-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-020-0612-z