Molecular glues induce novel protein–protein interactions to modulate protein function and downstream biology. A recent study unveils manumycin polyketides with multiple electrophilic centers as covalent molecular glues between UBR7 and TP53.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Stanton, B. Z. et al. Science 359, eaao5902 (2018).
Isobe, Y. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0557-2 (2020).
Crews, C. M. Chem. Biol. 17, 551–555 (2010).
Ito, T. et al. Science 327, 1345–1350 (2010).
Lu, G. et al. Science 343, 305–309 (2014).
Krönke, J. et al. Science 343, 301–305 (2014).
Han, T. et al. Science 356, eaal3755 (2017).
Uehara, T. et al. Nat. Chem. Biol. 13, 675–680 (2017).
Ting, T. C. et al. Cell Rep. 29, 1499–1510.e1496 (2019).
Ho, T. T., Tran, Q. T. & Chai, C. L. Future Med. Chem. 10, 1361–1368 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Zeng, Z., Han, T. Discovering Nature’s super glue. Nat Chem Biol 16, 1155–1156 (2020). https://doi.org/10.1038/s41589-020-0586-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-020-0586-x