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EXPANDED GENETIC CODES

A new path to tyrosine sulfation

Tyrosine sulfation is a common post-translational modification known to play critical roles in multiple bioprocesses. A cleverly engineered mammalian expanded genetic code now enables the direct co-translational incorporation of tyrosine sulfates into proteins to study their function in cellular contexts.

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Fig. 1: Two routes to sulfated proteins in mammalian cell.

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Correspondence to Chang C. Liu.

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Liu, C.C. A new path to tyrosine sulfation. Nat Chem Biol 16, 365–366 (2020). https://doi.org/10.1038/s41589-020-0482-4

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