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Solo act revealed to be duet

The last step of archaeosine biosynthesis was found to involve two enzymes, the previously known ArcS with lysine transfer activity and a novel identified radical SAM enzyme named RaSEA.

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Fig. 1: Biosynthetic pathway of archaeosine (G+).


  1. Grosjean, H. DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution (Landes Bioscience, 2009).

  2. Phillips, G. & de Crécy-Lagard, V. Curr. Opin. Microbiol. 14, 335–341 (2011).

    Article  CAS  Google Scholar 

  3. Sprinzl, M., Hartmann, T., Weber, J., Blank, J. & Zeidler, R. Nucleic Acids Res. 17, r1–r172 (1989).

    Article  CAS  Google Scholar 

  4. Yokogawa, T. et al. Nat. Chem. Biol. (2019).

    Article  Google Scholar 

  5. Sofia, H. J., Chen, G., Hetzler, B. G., Reyes-Spindola, J. F. & Miller, N. E. Nucleic Acids Res. 29, 1097–1106 (2001).

    Article  CAS  Google Scholar 

  6. Atta, M. et al. Biochim. Biophys. Acta 1824, 1223–1230 (2012).

    Article  CAS  Google Scholar 

  7. Atta, M. et al. Curr. Opin. Struct. Biol. 20, 684–692 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Mohamed Atta.

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Atta, M. Solo act revealed to be duet. Nat Chem Biol 15, 1132–1133 (2019).

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