The last step of archaeosine biosynthesis was found to involve two enzymes, the previously known ArcS with lysine transfer activity and a novel identified radical SAM enzyme named RaSEA.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Grosjean, H. DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution (Landes Bioscience, 2009).
Phillips, G. & de Crécy-Lagard, V. Curr. Opin. Microbiol. 14, 335–341 (2011).
Sprinzl, M., Hartmann, T., Weber, J., Blank, J. & Zeidler, R. Nucleic Acids Res. 17, r1–r172 (1989).
Yokogawa, T. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0390-7 (2019).
Sofia, H. J., Chen, G., Hetzler, B. G., Reyes-Spindola, J. F. & Miller, N. E. Nucleic Acids Res. 29, 1097–1106 (2001).
Atta, M. et al. Biochim. Biophys. Acta 1824, 1223–1230 (2012).
Atta, M. et al. Curr. Opin. Struct. Biol. 20, 684–692 (2010).
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Atta, M. Solo act revealed to be duet. Nat Chem Biol 15, 1132–1133 (2019). https://doi.org/10.1038/s41589-019-0406-3