Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NEUROBIOLOGY

Extracellular phosphorylation in axon pathfinding

Nature Chemical Biology volume 15, pages 1030–1031 (2019)Cite this article

Subjects

The growth and guidance of axons dictate their trajectories and are critical for neural-circuit formation. Research in this issue uncovers a new mechanism for regulation of axon growth and guidance that acts via extracellular phosphorylation of a receptor.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Modes of axon guidance receptor regulation.

References

  1. O’Donnell, M., Chance, R. K. & Bashaw, G. J. Annu. Rev. Neurosci. 32, 383–412 (2009).

    Article  Google Scholar 

  2. Harada, H. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0345-z (2019).

  3. Bordoli, M. R. et al. Cell 158, 1033–1044 (2014).

    Article  CAS  Google Scholar 

  4. Kania, A. & Klein, R. Nat. Rev. Mol. Cell Biol. 17, 240–256 (2016).

    Article  CAS  Google Scholar 

  5. Gorla, M. et al. Cell Rep. 26, 3298–3312.e4 (2019).

    Article  CAS  Google Scholar 

  6. Onishi, K. & Zou, Y. eLife 6, e25269 (2017).

    Article  Google Scholar 

  7. Bai, G. et al. Cell 144, 106–118 (2011).

    Article  CAS  Google Scholar 

  8. Takahashi, T. & Strittmatter, S. M. Neuron 29, 429–439 (2001).

    Article  CAS  Google Scholar 

  9. Hong, K. et al. Cell 97, 927–941 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Montreal Clinical Research Institute (IRCM), Montreal, Quebec, Canada

    Patricia T. Yam & Frederic Charron

  2. Department of Anatomy and Cell Biology, Division of Experimental Medicine, McGill University, Quebec, Canada

    Frederic Charron

  3. Department of Medicine, University of Montreal, Montreal, Quebec, Canada

    Frederic Charron

Authors
  1. Patricia T. Yam
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frederic Charron
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frederic Charron.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yam, P.T., Charron, F. Extracellular phosphorylation in axon pathfinding. Nat Chem Biol 15, 1030–1031 (2019). https://doi.org/10.1038/s41589-019-0383-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-019-0383-6

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing