Antibody–drug conjugates

Breaking up is hard to do

A comprehensive genetic screen reveals new cellular trafficking factors and linker-dependent requirements for antibody–drug conjugate (ADC) cytotoxicity. These new insights may guide the design of optimized ADCs.

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Fig. 1: Mechanisms for drug release from antibody–drug conjugates.


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Correspondence to Peter D. Senter.

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Competing interests

The authors are employees of Seattle Genetics, a company engaged in the field of antibody–drug conjugates.

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