RNA MODIFICATIONS

New roles for old RNA cap flavors

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The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs.

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Fig. 1: Structure of the 5′ cap on RNAs synthesized by RNA Pol II.

References

  1. 1.

    Edmonds, M., Vaughan, M. H.Jr. & Nakazato, H. Proc. Natl Acad. Sci. USA 68, 1336–1340 (1971).

  2. 2.

    Darnell, J. E., Wall, R. & Tushinski, R. J. Natl Acad. Sci. USA 68, 1321–1325 (1971).

  3. 3.

    Wei, C. M. & Moss, B. Proc. Natl Acad. Sci. USA 72, 318–322 (1975).

  4. 4.

    Furuichi, Y. et al. Proc. Natl Acad. Sci. USA 72, 1904–1908 (1975).

  5. 5.

    Perry, R. P. & Kelley, D. E. Cell 6, 13–19 (1975).

  6. 6.

    Mauer, J. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0231-8 (2019).

  7. 7.

    Akichika, S. et al. Science 363, eaav0080 (2019).

  8. 8.

    Smith, E. R. et al. Mol. Cell 44, 954–965 (2011).

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Correspondence to Richard A. Padgett.

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