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SYNTHETIC BIOLOGY

Protein circuits reprogram cells

Nature Chemical Biologyvolume 15pages9697 (2019) | Download Citation

Two protein circuit systems, split-protease-cleavable orthogonal coiled-coil logic (SPOC logic) and circuits of hacked orthogonal modular proteases (CHOMP), have been developed to permit rapid and logic function-based control of mammalian cellular signaling.

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Author information

Affiliations

  1. Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA

    • Yiqian Wu
    •  & Yingxiao Wang

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Yingxiao Wang.

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DOI

https://doi.org/10.1038/s41589-018-0210-5

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