New tricks for an old drug

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The prodrug dimethyloxalylglycine (DMOG) is a well-known tool compound used to study hypoxia. New findings reveal that DMOG also inhibits glutamine metabolism and can be exploited to selectively kill some cancer cells, highlighting important caveats when using DMOG for hypoxia studies.

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Fig. 1: DMOG metabolism and inhibitory activities.


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Correspondence to Costas A. Lyssiotis.

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Nelson, B.S., Kremer, D.M. & Lyssiotis, C.A. New tricks for an old drug. Nat Chem Biol 14, 990–991 (2018) doi:10.1038/s41589-018-0137-x

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