Spatial omics enables the molecular profiling of cells with the tissue context preserved. A new analytic approach shows how cellular neighborhood analysis and feature augmentation can spatially connect and cluster millions of cells into higher-order functional units.
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References
Lewis, S. M. et al. Nat. Methods. 18, 997–1012 (2021).
Atta, L. & Fan, J. Nat. Commun. 12, 5283 (2021).
Charitakis, M. et al. Genome Biol. 24, 209 (2023).
Singhal, V. et al. Nat. Genet. https://doi.org/10.1038/s41588-024-01664-3 (2024).
Gabor, D. J. Inst. Elec. Eng. 93, 429–457 (1946).
Long, Y. et al. Nat. Commun. 14, 1155 (2023).
Hu, J. et al. Nat. Methods 18, 1342–1351 (2021).
Zhao, E. et al. Nat. Biotechnol. 39, 1375–1384 (2021).
Chidester, B. et al. Nat. Genet. 55, 78–88 (2023).
Zubair, A. et al. Nucleic Acids Res. 50, e80 (2022).
Pham, D. et al. Nat. Commun. 14, 7739 (2023).
Acknowledgements
M.J.R. is supported by a Wings for Life Project Grant and a National Health and Medical Research Council (NHMRC) Project Grant (1163835). Q.N. is supported by an Australian Research Council DECRA Award (DE190100116), NHMRC Investigator Grant (GNT2008928) and NHMRC Project Grant (2001514).
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Ruitenberg, M.J., Nguyen, Q.H. Cellular neighborhood analysis in spatial omics reveals new tissue domains and cell subtypes. Nat Genet 56, 362–364 (2024). https://doi.org/10.1038/s41588-023-01646-x
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DOI: https://doi.org/10.1038/s41588-023-01646-x