Variants in the HLA region on chromosome 6 are strongly associated with many immune-related diseases. A method to construct personalized HLA genomes from single-cell RNA sequencing data, coupled with single-cell HLA expression quantitative trait loci modeling, identifies how genetic variants influence HLA gene expression across cell states.
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Kelly, J.A., Tessneer, K.L. & Gaffney, P.M. Taming the HLA for single-cell genomics. Nat Genet 55, 2025–2026 (2023). https://doi.org/10.1038/s41588-023-01590-w
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DOI: https://doi.org/10.1038/s41588-023-01590-w