EasySci, a scalable single-cell profiling technique, uncovered over 300 mammalian brain cell states, revealing molecular features and dynamics of rare cell states linked to aging and Alzheimer’s disease. This work offers insights into cell states that expand (rare astrocytes and vascular leptomeningeal cells in the olfactory bulb, reactive microglia, and oligodendrocytes) or are depleted (neuronal progenitors, neuroblasts and committed oligodendrocyte precursors) during normal and pathological aging.
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This is a summary of: Sziraki, A. et al. A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains. Nat. Genet. https://doi.org/10.1038/s41588-023-01572-y (2023).
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Aging- and Alzheimer’s disease-related rare cell type dynamics in the mammalian brain unveiled. Nat Genet 55, 2027–2028 (2023). https://doi.org/10.1038/s41588-023-01573-x
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DOI: https://doi.org/10.1038/s41588-023-01573-x
