The symmetric inheritance of histone modifications by the nascent chromatin fibers during DNA replication is essential for proper developmental progression. Two new studies using mouse embryonic stem cells further illuminate the role of histone inheritance in early cell fate decisions.
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Altamirano-Pacheco, L., Navarro, P. A fork in the road to differentiation. Nat Genet 55, 1422–1423 (2023). https://doi.org/10.1038/s41588-023-01489-6
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DOI: https://doi.org/10.1038/s41588-023-01489-6