Incidence of keratinocyte skin cancer varies markedly between populations living in different areas of the world. A detailed analysis of somatic mutations in the normal skin of individuals from the UK and Singapore reveals different patterns of clonal mutational landscapes that could contribute to differential risk.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Moan, J., Grigalavicius, M., Baturaite, Z., Dahlback, A. & Juzeniene, A. Photodermatol. Photoimmunol. Photomed. 31, 26–35 (2015).
Kolitz, E. et al. JAMA Dermatol. 158, 542–546 (2022).
Jones, P., Lucock, M., Veysey, M. & Beckett, E. Nutrients 10, 554 (2018).
Jablonski, N. G. & Chaplin, G. Proc. Biol. Sci. 281, 20140517 (2014).
Greaves, M. Proc. Biol. Sci. 281, 20132955 (2014).
Koh, D. et al. Br. J. Dermatol. 148, 1161–1166 (2003).
Martincorena, I. et al. Science 348, 880–886 (2015).
Fowler, J. C. et al. Cancer Discov. 11, 340–361 (2021).
King, C. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01468-x (2023).
Abby, E. et al. Nat. Genet. 55, 232–245 (2023).
Nasti, T. H. & Timares, L. Photochem. Photobiol. 91, 188–200 (2015).
Savoye, I. et al. J. Epidemiol. 28, 27–33 (2018).
Wu, S. et al. Am. J. Epidemiol. 183, 824–833 (2016).
Acknowledgements
J.D. is supported by US Veterans Administration Merit Grant 1 I01 BX004495.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
De Dominici, M., DeGregori, J. Our ancestry dictates clonal architecture and skin cancer susceptibility. Nat Genet 55, 1428–1429 (2023). https://doi.org/10.1038/s41588-023-01467-y
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-023-01467-y