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3D genomics

RNA Pol II enters the ring of cohesin-mediated loop extrusion

Nature Genetics volume 55, pages 1256–1258 (2023)Cite this article

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The three-dimensional organization of mammalian chromosomes can regulate transcription. Whether transcription itself influences genome structure has remained a source of debate. Using sensitive genome-wide readouts, two recent studies describe the involvement of transcription on genome architecture by different mechanisms.

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Fig. 1: Involvement of Pol II in loop formation by two different mechanisms.

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Authors and Affiliations

  1. Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

    Daan Noordermeer

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  1. Daan Noordermeer
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Correspondence to Daan Noordermeer.

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The author declares no competing interests.

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Noordermeer, D. RNA Pol II enters the ring of cohesin-mediated loop extrusion. Nat Genet 55, 1256–1258 (2023). https://doi.org/10.1038/s41588-023-01463-2

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