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Telomere biology

Nucleotide metabolism regulates human telomere length via telomerase activation

Nature Genetics volume 55, pages 532–533 (2023)Cite this article

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Telomere length is an important determinant of cellular aging and disease risk, but the genetics of telomere length control in humans is unclear. A genome-wide CRISPR screen has now identified a central role for thymidine nucleotide metabolism in the regulation of telomere length, which has implications for the diagnosis and treatment of disease.

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Fig. 1: Model for the impact of the nucleotide metabolism pathway on telomere lengthening.

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  1. Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, Australia

    Tracy M. Bryan

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  1. Tracy M. Bryan
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Correspondence to Tracy M. Bryan.

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The author declares no competing interests.

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Bryan, T.M. Nucleotide metabolism regulates human telomere length via telomerase activation. Nat Genet 55, 532–533 (2023). https://doi.org/10.1038/s41588-023-01359-1

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