Specific chromatin features, especially histone H3 lysine 27 acetylation, are widely used to identify active enhancers, yet current methods are imprecise. New work suggests that histone H2B N terminus multisite lysine acetylation (H2BNTac) is a notable signature of active enhancers and could substantially improve enhancer prediction.
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K.H. is a co-founder of Dania Therapeutics and a scientific advisor for Hannibal Innovation. He was recently a scientific advisor for Inthera Bioscience AG and MetaboMed Inc. C.H. declares no competing interests.
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Huang, C., Helin, K. Catching active enhancers via H2B N-terminal acetylation. Nat Genet 55, 525–526 (2023). https://doi.org/10.1038/s41588-023-01347-5
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DOI: https://doi.org/10.1038/s41588-023-01347-5
