Using laser-capture microdissection and whole-genome sequencing of individual crypts, we characterized the landscape of somatic mutations in human small intestinal epithelium. Mutational signatures of APOBEC mutagenesis were found frequently and are probably due to the activity of APOBEC1, which is expressed at high levels in the small intestine.
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This is a summary of: Wang, Y. et al. APOBEC mutagenesis is a common process in normal human small intestine. Nat. Genet. https://doi.org/10.1038/s41588-022-01296-5 (2023).
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Mutational signatures in human small intestinal crypts indicate APOBEC mutagenesis. Nat Genet 55, 176–177 (2023). https://doi.org/10.1038/s41588-023-01304-2