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Cancer genetics

NECTIN1 is a melanoma metastasis suppressor gene

Nature Genetics volume 54, pages 1776–1777 (2022)Cite this article

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Few genetic alterations have been linked to metastasis, during which cancer cells acquire abnormal migratory behavior. A new study sheds light on how loss of NECTIN1 leads to melanoma dissemination after local depletion of IGF1.

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Fig. 1: A model for melanoma metastasis.

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Authors and Affiliations

  1. Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, London, EC1M 6BQ, United Kingdom

    Jaume Barcelo & Victoria Sanz-Moreno

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  1. Jaume Barcelo
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  2. Victoria Sanz-Moreno
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Correspondence to Victoria Sanz-Moreno.

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The authors declare no competing interests.

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Barcelo, J., Sanz-Moreno, V. NECTIN1 is a melanoma metastasis suppressor gene. Nat Genet 54, 1776–1777 (2022). https://doi.org/10.1038/s41588-022-01229-2

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