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3D GENOMICS

Deciphering the regulatory logic of a chromatin domain boundary

The boundaries of chromatin domains have an important role in genome organization and regulation. A comprehensive genetic dissection of a domain boundary in vivo provides insights into how boundary elements function and cooperate to mediate insulation between chromatin domains.

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Fig. 1: Schematic summary of contact maps and Pax3 expression levels in the DelBs model and a selection of the additional mouse models presented in this study.

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Correspondence to A. Marieke Oudelaar.

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Oudelaar, A.M. Deciphering the regulatory logic of a chromatin domain boundary. Nat Genet 54, 914–915 (2022). https://doi.org/10.1038/s41588-022-01086-z

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