Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

WOMEN’S HEALTH

Using advanced spatial and single-cell transcriptomics to characterize the human endometrium

The human endometrium exhibits complex signaling cascades mediated by spatial–temporal cellular interactions. Understanding the normal endometrial microenvironment is the first step towards understanding diseases of endometrial dysfunction.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: The endometrium has a crucial role in female health.

References

  1. Greaves, E., Critchley, H. O. D., Horne, A. W. & Saunders, P. T. K. Acta Obstet. Gynecol. Scand. 96, 644–658 (2017).

    Article  Google Scholar 

  2. Maurya, V. K., DeMayo, F. J. & Lydon, J. P. Front. Cell. Dev. Biol. 9, 640907 (2021).

    Article  Google Scholar 

  3. Garcia-Alonso, L. Nat. Genet. https://doi.org/10.1038/s41588-021-00972-2 (2021).

  4. Wang, W. et al. Nat. Med. 26, 1644–1653 (2020).

    Article  CAS  Google Scholar 

  5. Kelleher, A. M., DeMayo, F. J. & Spencer, T. E. Endocr. Rev. 40, 1424–1445 (2019).

    Article  Google Scholar 

  6. Tempest, N., Maclean, A. & Hapangama, D. K. Int. J. Mol. Sci. 19, 3240 (2018).

    Article  Google Scholar 

  7. Burney, R. O. et al. Endocrinology 148, 3814–3826 (2007).

    Article  CAS  Google Scholar 

  8. Bulun, S. E. et al. Endocr. Rev. 40, 1048–1079 (2019).

    Article  Google Scholar 

  9. Flores, V. A., Vanhie, A., Dang, T. & Taylor, H. S. J. Clin. Endocrinol. Metab. 103, 4561–4568 (2018).

    Article  Google Scholar 

  10. Zhou, W., Menkhorst, E. & Dimitriadis, E. FASEB J. 35, e21784 (2021).

    CAS  PubMed  Google Scholar 

  11. Boretto, M. et al. Development 144, 1775–1786 (2017).

    CAS  PubMed  Google Scholar 

  12. Vallve-Juanico, J., Houshdaran, S. & Giudice, L. C. Hum. Reprod. Update 25, 564–591 (2019).

    Article  Google Scholar 

  13. Boretto, M. et al. Nat. Cell Biol. 21, 1041–1051 (2019).

    Article  CAS  Google Scholar 

  14. Turco, M. Y. et al. Nat. Cell Biol. 19, 568–577 (2017).

    Article  CAS  Google Scholar 

  15. Rawlings, T. M. et al. eLife 10, e69603 (2021).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shannon M. Hawkins.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, X., Hawkins, S.M. Using advanced spatial and single-cell transcriptomics to characterize the human endometrium. Nat Genet 53, 1628–1630 (2021). https://doi.org/10.1038/s41588-021-00982-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-021-00982-0

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing