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DEVELOPMENTAL EPIGENOMICS

The Polycomb landscape in mouse development

Polycomb-group proteins assemble into two primary complexes—Polycomb repressive complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new studies explore the PRC1 landscape during the transition from gametes to embryos in mice, thus providing insight into the intergenerational transmission of epigenetic information and gene regulation dynamics as embryos prepare for gastrulation.

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Fig. 1: Polycomb and transcriptional landscapes in normal and modified mouse embryos.

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Correspondence to Maxim V. C. Greenberg.

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Richard Albert, J., Greenberg, M.V.C. The Polycomb landscape in mouse development. Nat Genet 53, 427–429 (2021). https://doi.org/10.1038/s41588-021-00833-y

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