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DEVELOPMENTAL EPIGENOMICS

The Polycomb landscape in mouse development

Polycomb-group proteins assemble into two primary complexes—Polycomb repressive complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new studies explore the PRC1 landscape during the transition from gametes to embryos in mice, thus providing insight into the intergenerational transmission of epigenetic information and gene regulation dynamics as embryos prepare for gastrulation.

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Fig. 1: Polycomb and transcriptional landscapes in normal and modified mouse embryos.

References

  1. 1.

    Lagarou, A. et al. Genes Dev. 22, 2799–2810 (2008).

    CAS  Article  Google Scholar 

  2. 2.

    Tavares, L. et al. Cell 148, 664–678 (2012).

    CAS  Article  Google Scholar 

  3. 3.

    Blackledge, N. P. et al. Cell 157, 1445–1459 (2014).

    CAS  Article  Google Scholar 

  4. 4.

    Kahn, T. G. et al. Nucleic Acids Res. 44, 10132–10149 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Almeida, M. et al. Science 356, 1081–1084 (2017).

    CAS  Article  Google Scholar 

  6. 6.

    O’Carroll, D. et al. Mol. Cell. Biol. 21, 4330–4336 (2001).

    Article  Google Scholar 

  7. 7.

    Posfai, E. et al. Genes Dev. 26, 920–932 (2012).

    CAS  Article  Google Scholar 

  8. 8.

    Zheng, H. et al. Mol. Cell 63, 1066–1079 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Mei, H. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00820-3 (2021).

  10. 10.

    Chen, Z. et al. Nat. Genet. https://doi.org/10.1038/s41588-021-00821-2 (2021).

  11. 11.

    Skene, P. J. & Henikoff, S. eLife 6, e21856 (2017).

    Article  Google Scholar 

  12. 12.

    Xia, W. & Xie, W. Stem Cell Rep. 15, 1158–1175 (2020).

    CAS  Article  Google Scholar 

  13. 13.

    Wang, X. & Clark, A. G. Heredity 113, 156–166 (2014).

    CAS  Article  Google Scholar 

  14. 14.

    Inoue, A., Jiang, L., Lu, F., Suzuki, T. & Zhang, Y. Nature 547, 419–424 (2017).

    CAS  Article  Google Scholar 

  15. 15.

    Inoue, A., Chen, Z., Yin, Q. & Zhang, Y. Genes Dev. 32, 1525–1536 (2018).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Maxim V. C. Greenberg.

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Richard Albert, J., Greenberg, M.V.C. The Polycomb landscape in mouse development. Nat Genet 53, 427–429 (2021). https://doi.org/10.1038/s41588-021-00833-y

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