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Chromatin architecture is a flexible foundation for gene expression

The structure of chromatin is associated with its function, but precisely how is unclear. New data show that the higher-order architecture of the genome is similar among cell types with widely variant fates and gene expression patterns, thus challenging the view that chromatin domains determine function in the genome.

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Fig. 1: The emergence of chromatin domains.


  1. 1.

    Sexton, T. et al. Cell 148, 458–472 (2012).

    CAS  Article  Google Scholar 

  2. 2.

    Stadler, M. R., Haines, J. E. & Eisen, M. B. eLife 6, e29550 (2017).

    Article  Google Scholar 

  3. 3.

    Espinola, S. M. et al. Nat. Genet. (2021).

  4. 4.

    Ing-Simmons, E. et al. Nat. Genet. (2021).

    Article  PubMed  Google Scholar 

  5. 5.

    Cattoni, D. I. et al. Nat. Commun. 8, 1753 (2017).

    Article  Google Scholar 

  6. 6.

    Finn, E. H. et al. Cell 176, 1502–1515.e10 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Novo, C. L. et al. Cell Rep. 22, 2615–2627 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Chapski, D. J., Rosa-Garrido, M., Hua, N., Alber, F. & Vondriska, T. M. Front. Cardiovasc. Med. 5, 186 (2019).

    Article  Google Scholar 

  9. 9.

    Chen, H. et al. Nat. Genet. 50, 1296–1303 (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Shi, G., Liu, L., Hyeon, C. & Thirumalai, D. Nat. Commun. 9, 3161 (2018).

    Article  Google Scholar 

  11. 11.

    Bintu, B. et al. Science 362, eaau1783 (2018).

    Article  Google Scholar 

  12. 12.

    Heinz, S. et al. Cell 174, 1522–1536.e22 (2018).

    CAS  Article  Google Scholar 

  13. 13.

    Brandão, H. B. et al. Proc. Natl Acad. Sci. USA 116, 20489–20499 (2019).

    Article  Google Scholar 

  14. 14.

    Misteli, T. Cell 183, 28–45 (2020).

    CAS  Article  Google Scholar 

  15. 15.

    Finn, E. H. & Misteli, T. Science 365, eaaw9498 (2019).

    CAS  Article  Google Scholar 

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Correspondence to Tom Misteli or Elizabeth H. Finn.

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Misteli, T., Finn, E.H. Chromatin architecture is a flexible foundation for gene expression. Nat Genet 53, 426–427 (2021).

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