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FUNCTIONAL GENOMICS

Setting new boundaries with transcription and CTCF

How do boundary elements divide chromosomes into domains? A new study uses random genomic insertions to show how small genomic fragments can shape chromatin folding through the interplay of loop extrusion and compartmentalization. Spoiler: context matters.

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Fig. 1: A 2-kb insertion containing a promoter creates a new boundary.

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Correspondence to Elphège P. Nora.

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Anderson, E.C., Nora, E.P. Setting new boundaries with transcription and CTCF. Nat Genet 52, 1003–1004 (2020). https://doi.org/10.1038/s41588-020-0704-4

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