The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease.
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References
Lavi, U., Fernandez-Muñoz, R. & Darnell, J. E. Jr. Nucleic Acids Res. 4, 63–69 (1977).
Fitzsimmons, C. M. & Batista, P. J. Biochim. Biophys. Acta. Gene Regul. Mech. 1862, 382–393 (2019).
Bertero, A. et al. Nature 555, 256–259 (2018).
Kuppers, D. A. et al. Nat. Commun. 10, 4596 (2019).
Aguilo, F. et al. Cell Stem Cell 17, 689–704 (2015).
Liu, J. et al. Science 367, 580–586 (2020).
Huang, H. et al. Nature 567, 414–419 (2019).
Slobodin, B. et al. Cell 169, 326–337.e12 (2017).
Xiao, S. et al. Nat. Cell Biol. 21, 651–661 (2019).
Li, Y. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0677-3 (2020).
Zhang, Z. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0644-z (2020).
Schwartz, S. et al. Cell Rep. 8, 284–296 (2014).
Edupuganti, R. R. et al. Nat. Struct. Mol. Biol. 24, 870–878 (2017).
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Chan, D., Batista, P.J. RNA post-transcriptional modification speaks to chromatin. Nat Genet 52, 868–869 (2020). https://doi.org/10.1038/s41588-020-0685-3
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DOI: https://doi.org/10.1038/s41588-020-0685-3
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