Patterns of co-occurring and mutually exclusive mutations reveal synergistic interactions among cancer driver genes. A new study functionally confirms these interactions and builds the pairwise relationships into networks of pathway disruption that have better predictive power than specific mutations alone.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Bailey, M. H. et al. Cell 173, 371–385.e18 (2018).
Martincorena, I. et al. Cell 171, 1029–1041.e21 (2017).
Mina, M., Iyer, A., Tavernari, D., Raynaud, F. & Ciriello, G. Nat. Genet. https://doi.org/10.1038/s41588-020-0703-5 (2020).
Parmigiani, G. et al. Genomics 93, 17–21 (2009).
Boca, S. M., Kinzler, K. W., Velculescu, V. E., Vogelstein, B. & Parmigiani, G. Genome Biol. 11, R112 (2010).
Ciriello, G., Cerami, E., Sander, C. & Schultz, N. Genome Res. 22, 398–406 (2012).
Park, S. & Lehner, B. Mol. Syst. Biol. 11, 824 (2015).
Mina, M. et al. Cancer Cell 32, 155–168.e6 (2017).
McDonald, E. R. III et al. Cell 170, 577–592.e10 (2017).
Meyers, R. M. et al. Nat. Genet. 49, 1779–1784 (2017).
McFarland, J. M. et al. Nat. Commun. 9, 4610 (2018).
Behan, F. M. et al. Nature 568, 511–516 (2019).
Bateson, W. The Methods and Scope of Genetics (Cambridge Univ. Press, 1908); http://www.esp.org/foundations/genetics/classical/holdings/b/wb-methods-08.pdf
Martincorena, I. et al. Science 362, 911–917 (2018).
Martincorena, I. Genome Med. 11, 35 (2019).
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Taylor, M.S. Evolutionary dependencies show paths to cancer development. Nat Genet 52, 1135–1136 (2020). https://doi.org/10.1038/s41588-020-00728-4