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Modeling the cooperativity of schizophrenia risk genes

Common genetic variants increase the risk of schizophrenia, but the downstream biological mechanisms are largely unknown. A new study demonstrates that schizophrenia risk genes cause neuronal dysfunction and have synergistic effects on gene expression.

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Fig. 1: A genetics-anchored multifaceted approach to study the biological etiopathogenesis of schizophrenia.


  1. Pardiñas, A. F. et al. Nat. Genet. 50, 381–389 (2018).

    Article  Google Scholar 

  2. Langenberg, C. & Lotta, L. A. Lancet 391, 2463–2474 (2018).

    Article  CAS  Google Scholar 

  3. Musunuru, K. & Kathiresan, S. Cell 177, 132–145 (2019).

    Article  CAS  Google Scholar 

  4. Schrode, N. et al. Nat. Genet. (2019).

  5. Benner, C. et al. Bioinformatics 32, 1493–1501 (2016).

    Article  CAS  Google Scholar 

  6. Huckins, L. M. et al. Nat. Genet. 51, 659–674 (2019).

    Article  CAS  Google Scholar 

  7. Moslem, M., Olive, J. & Falk, A. Schizophr. Res. 210, 3–12 (2019).

    Article  Google Scholar 

  8. Schwartzentruber, J. et al. Nat. Genet. 50, 54–61 (2018).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Jane H. Christensen or Anders D. Børglum.

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Christensen, J.H., Børglum, A.D. Modeling the cooperativity of schizophrenia risk genes. Nat Genet 51, 1434–1436 (2019).

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