News & Views | Published:

DISEASE GENOMICS

Public resources aid diabetes gene discovery

Nature Geneticsvolume 50pages14991500 (2018) | Download Citation

The availability of various public resources has hastened the discovery of type 2 diabetes–associated loci in the largest genome-wide association study of the disease reported to date. In addition, these resources have also enabled researchers to get closer to determining the culprit genetic variants and therefore closer to the target effector genes driving these associations.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Change history

  • 05 November 2018

    In the version of this article originally published, the text was incorrect in the first paragraph of the ‘Remaining challenges’ section. The first two sentences appeared as “Even though this current study substantially increases the number of loci associated with T2D, only approximately 18% of the genetic component of T2D risk is explained by the total complement of genetic variants uncovered genome wide in Mahajan et al.6. Interestingly, only a small proportion of that heritability was explained by low-frequency or rare variants (~1.1%), thus potentially indicating that many more of these variants still remain to be characterized in even larger sample sizes.” However, they should have read “Even though this current study substantially increases the number of loci associated with T2D, only a proportion of the genetic component of T2D risk is explained by the total complement of genetic variants uncovered genome wide in Mahajan et al.6. Interestingly, only a relatively small proportion of that heritability was explained by low-frequency or rare variants, thus potentially indicating that many more of these variants still remain to be characterized in even larger sample sizes.” The text has been corrected in the HTML and PDF versions of the paper.

References

  1. 1.

    Zeggini, E. et al. Nat. Genet. 40, 638–645 (2008).

  2. 2.

    Voight, B. F. et al. Nat. Genet. 42, 579–589 (2010).

  3. 3.

    Morris, A. P. et al. Nat. Genet. 44, 981–990 (2012).

  4. 4.

    Mahajan, A. et al. Nat. Genet. 46, 234–244 (2014).

  5. 5.

    Scott, R. A. et al. Diabetes 66, 2888–2902 (2017).

  6. 6.

    Mahajan, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0241-6 (2018).

  7. 7.

    Grant, S. F. et al. Nat. Genet. 38, 320–323 (2006).

  8. 8.

    Palmer, N. D. et al. Diabetes 60, 662–668 (2011).

  9. 9.

    Gaulton, K. J. et al. Nat. Genet. 42, 255–259 (2010).

  10. 10.

    Maller, J. B. et al. Nat. Genet. 44, 1294–1301 (2012).

  11. 11.

    Yaghootkar, H. et al. Hum. Mol. Genet. 26, 1018–1030 (2017).

  12. 12.

    Manolio, T. A. et al. Nature 461, 747–753 (2009).

Download references

Author information

Affiliations

  1. Center for Spatial and Functional Genomics, Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    • Diana L. Cousminer
    •  & Struan F. A. Grant
  2. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    • Diana L. Cousminer
    •  & Struan F. A. Grant
  3. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    • Struan F. A. Grant
  4. Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    • Struan F. A. Grant
  5. Division of Endocrinology and Diabetes, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    • Struan F. A. Grant

Authors

  1. Search for Diana L. Cousminer in:

  2. Search for Struan F. A. Grant in:

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Struan F. A. Grant.

About this article

Publication history

Published

Issue Date

DOI

https://doi.org/10.1038/s41588-018-0242-5

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing