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DISEASE GENETICS

Genetic risks and clinical rewards

Nature Geneticsvolume 50pages12101211 (2018) | Download Citation

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Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility have been shown to yield both reliable and clinically meaningful results. However, certain impediments and outdated ways of thinking about health maintenance must be overcome before GPSs are adopted in routine care streams.

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References

  1. 1.

    Khera, A. V. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0183-z (2018).

  2. 2.

    Torkamani, A., Wineinger, N. E. & Topol, E. J. Nat. Rev. Genet. https://doi.org/10.1038/s41576-018-0018-x (2018).

  3. 3.

    Marigorta, U. M., Rodríguez, J. A., Gibson, G. & Navarro, A. Trends Genet. 34, 504–517 (2018).

  4. 4.

    Martin, A. R. et al. Am. J. Hum. Genet. 100, 635–649 (2017).

  5. 5.

    Yang, Q. et al. Am. J. Hum. Genet. 85, 786–800 (2009).

  6. 6.

    Desikan, R. S. et al. PLoS Med. 14, e1002258 (2017).

  7. 7.

    Patel, C. J. et al. Genome Med. 5, 58 (2013).

  8. 8.

    Schork, N. J. Genome Med. 5, 54 (2013).

  9. 9.

    Bloss, C. S., Schork, N. J. & Topol, E. J. N. Engl. J. Med. 364, 524–534 (2011).

  10. 10.

    Helgesson, G. J. Law Med. Ethics 42, 28–37 (2014).

  11. 11.

    Nguyen, T. N. et al. Am. Health Drug Benefits 9, 475–485 (2016).

  12. 12.

    Brainstorm Consortium et al. Science 360, eaap8757 (2018).

  13. 13.

    Wang, Y. et al. Mult. Scler. 22, 1783–1793 (2016).

  14. 14.

    Yokoyama, J. S. et al. JAMA Neurol. 73, 691–697 (2016).

  15. 15.

    Schork, N. J. & Topol, E. J. J. Biopharm. Stat. 20, 315–333 (2010).

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Author information

Affiliations

  1. Institute for Biological Psychiatry, Mental Health Services Snct. Hans, Roskilde, Denmark

    • Andrew J. Schork
  2. Department of Biostatistics (Emeritus), University of Michigan, Ann Arbor, MI, USA

    • M. Anthony Schork
  3. Department of Quantitative Medicine, The Translational Genomics Research Institute (TGen), Phoenix, AZ, USA

    • Nicholas J. Schork
  4. The IMPACT Center, City of Hope, Duarte, CA, USA

    • Nicholas J. Schork
  5. Human Biology, J. Craig Venter Institute, La Jolla, CA, USA

    • Nicholas J. Schork
  6. Departments of Psychiatry and of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA

    • Nicholas J. Schork

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Nicholas J. Schork.

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DOI

https://doi.org/10.1038/s41588-018-0213-x

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