Correspondence | Published:

Subfunctionalization versus neofunctionalization after whole-genome duplication

Nature Geneticsvolume 50pages908909 (2018) | Download Citation

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from $8.99

All prices are NET prices.


  1. 1.

    Lynch, M. & Conery, J. S. Science 290, 1151–1155 (2000).

  2. 2.

    Ohno, S. Evolution by Gene Duplication (Springer, Berlin, 1970).

  3. 3.

    Lien, S. et al. Nature 533, 200–205 (2016).

  4. 4.

    Braasch, I. et al. Nat. Genet. 48, 427–437 (2016).

  5. 5.

    Rohlfs, R. V. & Nielsen, R. Syst. Biol. 64, 695–708 (2015).

  6. 6.

    Felsenstein, J. Am. Nat. 125, 1–15 (1985).

  7. 7.

    Martins, E. P. & Hansen, T. F. Am. Nat. 149, 646–667 (1997).

  8. 8.

    Revell, L. J. Methods Ecol. Evol. 3, 217–223 (2012).

Download references


S.R.S. was supported by Norwegian Research Council projects 221734 and 244164.

Author information


  1. Center for Integrative Genetics (CIGENE), Faculty of Biosciences, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway

    • Simen R. Sandve
  2. Department of Biology, San Francisco State University, San Francisco, CA, USA

    • Rori V. Rohlfs
  3. Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway

    • Torgeir R. Hvidsten
  4. Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, Umeå, Sweden

    • Torgeir R. Hvidsten


  1. Search for Simen R. Sandve in:

  2. Search for Rori V. Rohlfs in:

  3. Search for Torgeir R. Hvidsten in:


S.R.S. and T.R.H. conceived the study. T.R.H. analyzed the expression data, and R.V.R. performed the simulations. All authors interpreted the results and wrote and approved the manuscript for publication.

Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Simen R. Sandve or Torgeir R. Hvidsten.

Supplementary information

About this article

Publication history