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Sizing up whole-genome sequencing studies of common diseases

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The triplet code underpins analyses of rare and de novo mutations in exome sequencing data, but analysis of the noncoding genome is much more challenging. A new analytical framework for common, complex diseases highlights the need for very large samples to overcome the unavoidable multiple-testing burden and hence provides preemptive warnings against underpowered studies.

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Author information

Affiliations

  1. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

    • Naomi R. Wray
    •  & Jacob Gratten
  2. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia

    • Naomi R. Wray

Authors

  1. Search for Naomi R. Wray in:

  2. Search for Jacob Gratten in:

Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Naomi R. Wray or Jacob Gratten.

Supplementary information