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Elucidating the genetics of craniofacial shape

Alterations in craniofacial size and shape are apparent in many monogenic diseases and syndromes, but remarkably little is known about the genetics of face shape within healthy populations. This may be set to change following publication of a study that combines unsupervised hierarchical spectral clustering and canonical correlation analysis to help identify common genetic variants associated with craniofacial shape.

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  1. 1.

    Adhikari, K. et al. Nat. Commun. 7, 11616 (2016).

  2. 2.

    Cole, J. B. et al. PLoS Genet. 12, e1006174 (2016).

  3. 3.

    Lee, M. K. et al. PLoS One 12, e0176566 (2017).

  4. 4.

    Liu, F. et al. PLoS Genet. 8, e1002932 (2012).

  5. 5.

    Paternoster, L. et al. Am. J. Hum. Genet. 90, 478–485 (2012).

  6. 6.

    Shaffer, J. R. et al. PLoS Genet. 12, e1006149 (2016).

  7. 7.

    Claes, P. et al. Nat. Genet. (2018).

  8. 8.

    Ng, A. Y., Jordan, M. I. & Weiss, Y. in Advances in Neural Information Processing Systems (eds. Dietterich, T. G., Becker, S. & Ghahramani, Z.) Vol. 14, 849–856 (MIT Press, Cambridge, MA, 2001).

  9. 9.

    Pickrell, J. K. et al. Nat. Genet. 48, 709–717 (2016).

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Author information


  1. University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

    • David M. Evans
  2. Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK

    • David M. Evans


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Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to David M. Evans.