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GENE REGULATION

Pioneering the chromatin landscape

New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.

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Fig. 1: Dynamics of pioneer-factor activity.

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Correspondence to Kenneth S. Zaret.

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Zaret, K.S. Pioneering the chromatin landscape. Nat Genet 50, 167–169 (2018). https://doi.org/10.1038/s41588-017-0038-z

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