Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER METABOLISM

Genetics of lipid metabolism in prostate cancer

Nature Genetics volume 50, pages 169–171 (2018)Cite this article

Subjects

Dysregulated lipid metabolism is a prominent feature of prostate cancers. Two papers in this issue identify novel genomic drivers of lipid metabolism in prostate cancer and provide implications for the subtyping and treatment of the disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic diagram showing two genomic drivers of aberrant lipid metabolism contributing to tumor growth and metastasis in prostate cancer (CaP).

References

  1. Butler, L. M., Centenera, M. M. & Swinnen, J. V. Endocr. Relat. Cancer 23, R219–R227 (2016).

    Article  CAS  Google Scholar 

  2. Schuster, D. M., Nanni, C. & Fanti, S. Semin. Nucl. Med. 46, 507–521 (2016).

    Article  Google Scholar 

  3. Migita, T. et al. J. Natl. Cancer Inst. 101, 519–532 (2009).

    Article  CAS  Google Scholar 

  4. Sadowski, M. C. et al. Oncotarget 5, 9362–9381 (2014).

    Article  Google Scholar 

  5. Kridel, S. J., Axelrod, F., Rozenkrantz, N. & Smith, J. W. Cancer Res. 64, 2070–2075 (2004).

    Article  CAS  Google Scholar 

  6. Allott, E. H., Masko, E. M. & Freedland, S. J. Eur. Urol. 63, 800–809 (2013).

    Article  CAS  Google Scholar 

  7. Chen, J. et al. Nat. Genet. https://doi.org/10.1038/s41588-017-0026-3 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Chen, M. et al. Nat. Genet. https://doi.org/10.1038/s41588-017-0027-2 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wellen, K. E. et al. Science 324, 1076–1080 (2009).

    Article  CAS  Google Scholar 

  10. Cucchiara, V. et al. Eur. Urol. https://doi.org/10.1016/j.eururo.2017.10.036 (2017).

    Article  PubMed  Google Scholar 

  11. Lamy, P. J. et al. Eur. Urol. Focus. https://doi.org/10.1016/j.euf.2017.02.017 (2017).

    Article  PubMed  Google Scholar 

  12. Priolo, C. et al. Cancer Res. 74, 7198–7204 (2014).

    Article  CAS  Google Scholar 

  13. Baena, E. et al. Genes Dev. 27, 683–698 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, Belfast, UK

    Ninu Poulose, Francesca Amoroso, Rebecca E. Steele, Reema Singh, Chee Wee Ong & Ian G. Mills

  2. Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK

    Ian G. Mills

Authors
  1. Ninu Poulose
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesca Amoroso
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rebecca E. Steele
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Reema Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chee Wee Ong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ian G. Mills
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ian G. Mills.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Poulose, N., Amoroso, F., Steele, R. et al. Genetics of lipid metabolism in prostate cancer. Nat Genet 50, 169–171 (2018). https://doi.org/10.1038/s41588-017-0037-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-017-0037-0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer