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Traumatic brain injury

Clinical outcomes evolve years after traumatic brain injury

The TRACK-TBI LONG study has shown that outcomes are highly variable in the 7 years after traumatic brain injury (TBI). Although many patients remain stable, almost one-third experience declines in cognitive, psychiatric and functional state. These findings suggest that TBI is a chronic disease and that its management should change accordingly.

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References

  1. Maas, A. I. R. et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 21, 1004–1060 (2022).

    Article  PubMed  Google Scholar 

  2. Murray, C. J. et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197–2223 (2012).

    Article  PubMed  Google Scholar 

  3. Brett, B. L. et al. Long-term multi-domain patterns of change following traumatic brain injury: a TRACK-TBI LONG study. Neurology https://doi.org/10.1212/WNL.0000000000207501 (2023).

    Article  PubMed  Google Scholar 

  4. Whitnall, L., McMillan, T. M., Murray, G. D. & Teasdale, G. M. Disability in young people and adults after head injury: 5–7 year follow up of a prospective cohort study. J. Neurol. Neurosurg. Psychiatry 77, 640–645 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hammond, F. M., Hart, T., Bushnik, T., Corrigan, J. D. & Sasser, H. Change and predictors of change in communication, cognition, and social function between 1 and 5 years after traumatic brain injury. J. Head Trauma Rehabil. 19, 314–328 (2004).

    Article  PubMed  Google Scholar 

  6. Li, L. M. et al. Management of traumatic brain injury (TBI): a clinical neuroscience-led pathway for the NHS. Clin. Med. (Lond.) 21, e198–e205 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Tenovuo, O. et al. Assessing the severity of traumatic brain injury — time for a change? J. Clin. Med. 10, 148 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Graham, N. S. N. et al. Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury. Sci. Transl. Med. 13, eabg9922 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Smith, D. H., Johnson, V. E. & Stewart, W. Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nat. Rev. Neurol. 9, 211–221 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Scott, G. et al. Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration. Brain 141, 459–471 (2018).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge support from the UK National Institute for Health Research (NIHR) Academic Clinical Lectureship (N.S.N.G.), the UK Dementia Research Institute Care Research and Technology Centre (N.S.N.G. and D.J.S.) and the NIHR Clinical Research Facility and Biomedical Research Centre (BRC) at Imperial College Healthcare NHS Trust (N.S.N.G. and D.J.S.).

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Correspondence to David J. Sharp.

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D.J.S. serves on the concussion advisory board of the UK Rugby Football Union and undertakes clinical private practice including medicolegal assessments. D.J.S. has received research funding from the Rugby Football Union, Premiership Rugby and the Football Association (UK). N.S.N.G. declares no competing interests.

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Sharp, D.J., Graham, N.S.N. Clinical outcomes evolve years after traumatic brain injury. Nat Rev Neurol 19, 579–580 (2023). https://doi.org/10.1038/s41582-023-00868-1

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