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First trials test targeting of α-synuclein for Parkinson disease

In the first two phase II trials of therapies that target α-synuclein to treat Parkinson disease, the primary endpoints were not met. However, the limitations of these studies need to be addressed in future trials and alternative approaches to targeting α-synuclein should be pursued before α-synuclein is discounted as a target.

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Correspondence to Lorraine V. Kalia.

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Competing interests

L.V.K. has received consultation fees from AC Immune and UCB in the past year.

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Kalia, L.V. First trials test targeting of α-synuclein for Parkinson disease. Nat Rev Neurol 18, 703–704 (2022).

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