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ALZHEIMER DISEASE

The challenges of anti-tau therapeutics in Alzheimer disease

Nature Reviews Neurology volume 18, pages 577–578 (2022)Cite this article

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A phase II trial of the tau antibody semorinemab indicates that it has no clinical benefit in the earliest stages of Alzheimer disease. The repeated finding that antibody-mediated reductions in protein pathology have limited or no clinical benefit indicates that we need to consider more specific or combined therapeutic targets.

Refers to Teng, E. et al. Safety and efficacy of semorinemab in individuals with prodromal to mild Alzheimer disease: a randomized clinical trial. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2022.1375 (2022).

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Authors and Affiliations

  1. Unit of Research Methodology and Data Sciences for Population Health, National Institute of Gastroenterology “Saverio de Bellis”, Research Hospital, Castellana Grotte, Bari, Italy

    Francesco Panza

  2. Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy

    Madia Lozupone

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  1. Francesco Panza
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  2. Madia Lozupone
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Correspondence to Francesco Panza.

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The authors declare no competing interests.

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Panza, F., Lozupone, M. The challenges of anti-tau therapeutics in Alzheimer disease. Nat Rev Neurol 18, 577–578 (2022). https://doi.org/10.1038/s41582-022-00702-0

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  • DOI: https://doi.org/10.1038/s41582-022-00702-0

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