A new case series describes a cohort of individuals with severe psychiatric presentations who were diagnosed with ‘possible’ or ‘probable’ autoimmune encephalitis on the basis of neurological examination. Many participants improved after treatment with immunotherapy, highlighting the importance of fostering a closer relationship between the fields of neurology and psychiatry.
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References
National Institute for Health and Care Excellence. Psychosis and Schizophrenia in Adults: Prevention and Management, https://www.nice.org.uk/guidance/cg178/resources/psychosis-and-schizophrenia-in-adults-prevention-and-management-pdf-35109758952133 (NICE, 2014).
Endres, D. et al. Clinical manifestations and immunomodulatory treatment experiences in psychiatric patients with suspected autoimmune encephalitis: a case series of 91 patients from Germany. Mol. Psychiatry (2022).
Graus, F. et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 15, 391–404 (2016).
Nosadini, M. et al. Use and safety of immunotherapeutic management of N-methyl-d-aspartate receptor antibody encephalitis: a meta-analysis. JAMA Neurol. 78, 1333–1344 (2021).
Cullen, A. E. et al. Influence of methodological and patient factors on serum NMDAR IgG antibody detection in psychotic disorders: a meta-analysis of cross-sectional and case-control studies. Lancet Psychiatry 8, 109–120 (2021).
Scott, J. G. et al. The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis. BJPsych Open 4, 69–74 (2018).
Acknowledgements
B.R.L. is an honorary consultant psychiatrist at Oxford Health Foundation Trust and receives funding from the NIHR Oxford Health Biomedical Research Centre. B.R.L. thanks P. Harrison and G. Lennox for helpful feedback on the manuscript.
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B.R.L. is running a trial of immunotherapy in antibody-positive psychosis, SINAPPS2 (www.sinapps.org.uk), and has received research funding for related research from Janssen.
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Lennox, B.R. Challenging the psychiatry–neurology divide: the case of autoimmune encephalitis. Nat Rev Neurol 18, 253–254 (2022). https://doi.org/10.1038/s41582-022-00636-7
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DOI: https://doi.org/10.1038/s41582-022-00636-7