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Disease-modifying therapy aids cognition in multiple sclerosis

A new meta-analysis indicates that multiple sclerosis disease-modifying therapies (DMTs) have positive effects on cognition. High-efficacy and medium-efficacy DMTs apparently had comparable cognitive benefits; however, limitations of the original studies, including brief duration, restricted assessment and failure to account for baseline cognitive impairment, might limit the interpretation of the findings.

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Correspondence to Maria Pia Amato.

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Competing interests

M.P.A. has received research grants from Biogen, Merck, Teva, Roche, Novartis and Sanofi Genzyme and honoraria as a speaker and advisory board member from Biogen, Merck, Teva, Roche, Novartis and Sanofi Genzyme. L.B.K. has received consulting fees, served on data and safety monitoring boards or received grant support from Biogen, Novartis, Sanofi and Genzyme, and has received licensing fees from various pharmaceutical and biomedical companies for the Fatigue Severity Scale.

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Amato, M.P., Krupp, L.B. Disease-modifying therapy aids cognition in multiple sclerosis. Nat Rev Neurol 16, 525–526 (2020).

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