An understanding of the biochemical processes underlying Parkinson disease (PD) will be essential for the development of disease-modifying therapies. In a recent study, a novel biochemical phenotype of the disease was identified from analysis of inducible pluripotent stem cell-derived dopaminergic neurons from individuals with young-onset PD.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness
npj Parkinson's Disease Open Access 09 January 2024
-
Are the digit ratio (2D:4D) and hand grip strength related to Parkinson disease in elderly males?
BMC Sports Science, Medicine and Rehabilitation Open Access 20 March 2023
-
Incidence of Parkinson disease in North America
npj Parkinson's Disease Open Access 15 December 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Marras, C. et al. Prevalence of Parkinson’s disease across North America. NPJ Parkinsons Dis. 4, 21 (2018).
Toulorge, D., Schapira, A. H. V. & Hajj, R. Molecular changes in the postmortem parkinsonian brain. J. Neurochem. 139, 27–58 (2016).
Kilarski, L. L. et al. Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson’s disease. Mov. Disord. 27, 1522–1529 (2012).
Nalls, M. A. et al. Genetic risk and age in Parkinson’s disease: continuum not stratum. Mov. Disord. 30, 850–854 (2015).
Malek, N. et al. Features of GBA-associated Parkinson’s disease at presentation in the UK Tracking Parkinson’s study. J. Neurol. Neurosurg. Psychiatry 89, 702–709 (2018).
Laperle, A. H. et al. iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates. Nat. Med. 26, 289–299 (2020).
Burbulla, L. F. et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease. Science 357, 1255–1261 (2017).
Robak, L. A. et al. Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease. Brain 140, 3191–3203 (2017).
Balestrino, R. & Schapira, A. H. V. Glucocerebrosidase and Parkinson disease: molecular, clinical, and therapeutic implications. Neuroscientist 24, 540–559 (2018).
Mullin, S. et al. Ambroxol for the treatment of patients with Parkinson disease with and without glucocerebrosidase gene mutations: a nonrandomized, noncontrolled trial. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2019.4611 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Schapira, A.H.V., Morris, H.R. Pathogenetic insights into young-onset Parkinson disease. Nat Rev Neurol 16, 245–246 (2020). https://doi.org/10.1038/s41582-020-0343-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41582-020-0343-5
This article is cited by
-
Different risks of early-onset and late-onset Parkinson disease in individuals with mental illness
npj Parkinson's Disease (2024)
-
Are the digit ratio (2D:4D) and hand grip strength related to Parkinson disease in elderly males?
BMC Sports Science, Medicine and Rehabilitation (2023)
-
Incidence of Parkinson disease in North America
npj Parkinson's Disease (2022)