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Drug-resistant epilepsy — time to target mechanisms

Nature Reviews Neurology volume 16, pages 595–596 (2020)Cite this article

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Despite the development of many new anti-seizure drugs over the past two decades, around one-third of individuals with epilepsy are without effective treatment. This pharmacoresistance is poorly understood, but new treatments targeting epileptogenesis instead of seizures have shown potential in animal models and are now being translated into the clinic.

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Acknowledgements

The work of H.L. is supported by the German Research Foundation (DFG, Research Unit FOR-2715, grants Le 1030/14-1, /15-1 and /16-1) and by the Federal Ministry for Education and Research (BMBF, Treat-ION, 01GM1907A).

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Authors and Affiliations

  1. Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

    Holger Lerche

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  1. Holger Lerche
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Correspondence to Holger Lerche.

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Competing interests

H.L. has received personal honoraria for consulting or speaking from Arvelle, Bial, Biomarin, Desitin, Eisai and UCB; travel support from Bial, Desitin, Eisai and UCB; and research support from Bial, none directly related to any of the work presented here. He is a clinical investigator of the eslicarbazepine acetate trial (EudraCT Number: 2018-002747-29).

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Lerche, H. Drug-resistant epilepsy — time to target mechanisms. Nat Rev Neurol 16, 595–596 (2020). https://doi.org/10.1038/s41582-020-00419-y

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