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Alzheimer disease and aducanumab: adjusting our approach

In the march towards disease-modifying treatments for Alzheimer disease, immunotherapy with antibodies against amyloid-β protein is furthest along in human trials. The news that Biogen’s aducanumab showed no cognitive benefit in phase III trials requires careful analysis of what went wrong and how to position anti-amyloid agents among other therapeutic approaches.

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Correspondence to Dennis J. Selkoe.

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D.J.S. is a consultant for E-Scape Bio and Prothena.

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Selkoe, D.J. Alzheimer disease and aducanumab: adjusting our approach. Nat Rev Neurol 15, 365–366 (2019). https://doi.org/10.1038/s41582-019-0205-1

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