News & Views | Published:


Stroke prediction and the future of prognosis research

In a new study of 1,102 patients, a multi-item prognostic tool has been developed and validated for use in acute stroke. Using a mix of clinical variables (age and stroke severity), a process variable (administration of thrombolysis) and a biomarker (plasma copeptin), the authors were able to predict 3-month disability.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Drozdowska, B. A., Singh, S. & Quinn, T. J. Thinking about the future: a review of prognostic scales used in acute stroke. Front. Neurol. 10, 274 (2019).

  2. 2.

    De Marchis, G. M. et al. A novel biomarker-based prognostic score in acute ischemic stroke: the CoRisk score. Neurology 92, e1517–e1525 (2019).

  3. 3.

    Lipinski, M. J. et al. A systematic review and collaborative meta-analysis to determine the incremental value of copeptin for rapid rule-out of acute myocardial infarction. Am. J. Cardiol. 113, 1581–1591 (2014).

  4. 4.

    Ramalho, A. et al. Copeptin predicts long term prognosis in patients with worsening heart failure [abstract P1418]. Eur. J. Heart Fail. 16 (Suppl. 2), 276 (2014).

  5. 5.

    Steyerberg, E. W. et al. Prognosis research strategy (PROGRESS) 3: prognostic model research. PLOS Med. 10, e1001381 (2013).

  6. 6.

    Smith, W. S. et al. Brief history of endovascular acute ischaemic stroke treatment. Stroke 47, e23–e36 (2016).

  7. 7.

    Fahey, M. et al. Clinical prediction models for mortality and functional outcome following ischemic stroke: a systematic review and meta-analysis. PLOS ONE 13, e0185402 (2018).

  8. 8.

    Ntaios, G. et al. ASTRAL, DRAGON and SEDAN scores predict stroke outcome more accurately than physicians. Eur. J. Neurol. 23, 1651–1657 (2016).

  9. 9.

    Quinn, T. J. et al. Validating and comparing stroke prognosis scales. Neurology 89, 997–1002 (2017).

  10. 10.

    Takwoingi, Y. & Quinn, T. J. Review of Diagnostic Test Accuracy (DTA) studies in older people. Age Ageing 47, 349–355 (2018).

Download references


T.J.Q. is supported by a joint Chief Scientist Office and Stroke Association Senior Lectureship, grant reference TSA LECT 2015/05. B.A.D. is supported through the Stroke Association Priority Program Award, grant reference PPA 2015/01_CSO.

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Terence J. Quinn.

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.

About this article

Publication history

  • Published


Fig. 1: Outcome predictions based on the CoRisk score in a hypothetical sample of stroke patients.