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Ageing

Chronic kidney disease promotes ageing in a multiorgan disease network

Nature Reviews Nephrology volume 19, pages 542–543 (2023)Cite this article

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Human ageing trajectories are highly individual and dependent on genetic and non-genetic factors. An analysis of the interconnectivity of distinct age-related chronic diseases shows that organ-specific chronic diseases accelerate the ageing of other organ systems, which has important implications for mortality. Notably, chronic kidney disease was identified a highly important risk factor for the ageing of other organ systems.

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Fig. 1: Kidney function has a crucial role in the ageing process.

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Authors and Affiliations

  1. Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

    Thomas Benzing

  2. Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

    Thomas Benzing & Björn Schumacher

  3. Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne, Cologne, Germany

    Björn Schumacher

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  1. Thomas Benzing
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  2. Björn Schumacher
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Correspondence to Thomas Benzing.

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The authors declare no competing interests.

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Benzing, T., Schumacher, B. Chronic kidney disease promotes ageing in a multiorgan disease network. Nat Rev Nephrol 19, 542–543 (2023). https://doi.org/10.1038/s41581-023-00729-6

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